N E U R O T O X I N S |
alpha-neurotoxins | Postsynaptic neurotoxins that block the acetylcholine receptor (neuromuscular) | Elapid venoms only in snakes, also found in spiders and cone snails |
alpha-toxin (scorpion) | Presynaptic neurotoxins that act upon sodium channels of mammals | Scorpions |
beta-toxin (scorpion) | Presynaptic neurotoxins that act upon sodium channels of mammals | Scorpions |
Conatokins | inhibitiors of N-methyl-D- aspartate (NMDA) receptors resulting in an inhibition of NMDA receptor-mediated calcium influx in central nervous system neurons | Cone snails |
Fasiculins | Acetylcholinesterase | Dendroaspis (mamba) species |
kappa-neurotoxins | Postsynaptic neurotoxins that block the acetylcholine receptors (neuronal) | Elapid venoms only |
Long and short neurotoxins | Postsynaptic neurotoxins that block the acetylcholine receptors | Elapid venoms only in snakes |
mu-toxins | Directly abolish muscle action potentials through the inhibition of muscle sodium channels | spider and cone snail |
omega-neurotoxins | Prevent voltage-activated entry of calcium into the nerve terminal and release of acetylcholine | cone snails and spiders |
PLA2s | Presynaptic destruction of nerve cell | PLA2s are widespread in venoms |
P3 | High molecular weight toxins from Physalia physalis (portugese man o'war) that reversibly blocks glutamate receptors which are integral parts of the nerve conductance system | Portugues man o'war |
Tetrodotoxin-like | acute respiratory failure through paralysis of the respiratory musculature with death as a result | Blue-ringed octopi, poison dart frogs, pufferfish |